Naltrexone for Weight Loss: A Breakthrough in Healthy Living

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Naltrexone for Weight Loss: A Breakthrough in Healthy Living

The Truth About Using Naltrexone for Weight Loss

Could a drug commonly used to treat alcohol and opioid addiction also aid weight loss? Recent research indicates the medication naltrexone may support dieting efforts and weight control through appetite suppression and reduced cravings. Sold alone under the brand name Revia or combined with bupropion as Contrave, naltrexone represents an “off-label” pharmaceutical approach to slimming down. But is it effective and safe for weight loss? Let’s analyze the evidence. This article will tackle how Naltrexone for Weight Loss Works, its potential benefits, and drawbacks, and answer frequently asked questions.

How Naltrexone for Weight Loss Works

A woman measures her waist using a tape measure, ensuring accurate results for tracking her fitness progress

Naltrexone for Weight Loss is thought to promote weight reduction through several mechanisms:

  • Appetite suppression – By blocking opiate receptors, naltrexone reduces hunger drive and cravings for calorie-dense foods. This results in consuming fewer daily calories.
  • Reduced reward – It minimizes the pleasurable feelings associated with sugary and fatty foods. This makes overeating less rewarding psychologically.
  • Lower insulin – Early evidence links naltrexone with decreased insulin secretion after meals. Lower insulin could reduce fat storage.
  • Anti-addiction – Some compulsive overeating behaviors share brain pathways with addiction. Naltrexone helps curb cravings and urges to snack.
  • Accelerated metabolism – One study found naltrexone increased resting metabolic rate compared to placebo. However other trials found no metabolic effect.

Analyzing the Research on Naltrexone for Weight Loss

While a few small studies show modest weight reduction, high-quality evidence overall is lacking:

  • Short duration – Most clinical trials analyzed use for only 4-12 weeks. Long-term efficacy and safety remain unclear.
  • Small samples – Studies include 15-40 participants on average. Larger scale, multi-center trials are still needed.
  • Dropouts – Many participants fail to complete the full study protocol. This makes interpreting effectiveness difficult.
  • Varied dosing – Optimal dosing for weight loss is not firmly established. Daily doses ranged widely from 25mg to 300 mg in trials.
  • Adjunct treatment – Participants are encouraged to follow reduced-calorie diets and get counseling. True isolated drug effects are unknown.
  • Commercial bias – Some research is funded by authors affiliated with drug manufacturers, raising the risk of analyzed bias.

Potential Benefits of Naltrexone for Weight Loss

Despite limitations, possible advantages of using naltrexone include:

  • 3-5% weight reduction – Some high-quality 12-16 week studies show modest but meaningful weight loss.
  • Reduced cravings – Participants report fewer food cravings and less compulsive eating behavior.
  • Well-tolerated – Nausea is the primary side effect, but it tends to resolve after the first week at lower dosing.
  • Enhanced compliance – By reducing addictive food urges, users are more successful in maintaining dietary changes needed for weight loss.

Drawbacks and Warnings

However, there are notable potential downsides and risks including:

  • Expense – About $100-200 monthly without insurance coverage. Contrave costs closer to $1200 monthly.
  • Gastrointestinal issues – Nausea, vomiting, and diarrhea commonly occur. Taking with food and starting with lower doses helps.
  • Headache and dizziness – Headaches are a common complaint along with lightheadedness from orthostatic hypotension.
  • Depression risks at high doses – Naltrexone blocks endorphins and may exacerbate mood disorders. Close monitoring is required.
  • No long-term safety data – Effects beyond 16 weeks remain unknown. There are concerns for toxicity with chronic use.
  • Rebound overeating when stopped – Compulsive eating may return stronger post-treatment if underlying psychological factors are unaddressed.

Guidelines for Using Naltrexone for Weight Loss Safely

  • Use under close medical supervision only, typically with a psychiatric prescriber.
  • Start at a lower dosage (25-50mg) for a week before slowly increasing to minimize side effects.
  • Take on a full stomach to reduce nausea.
  • Stay well hydrated to prevent headaches and dizziness.
  • Monitor for changes in mood or behavior indicating depression or suicidal thoughts.
  • Do not use it if you have acute hepatitis or liver failure.
  • Use contraception as effects on fetal development are unknown.
  • Report any worrisome side effects immediately rather than waiting for the next appointment.

The Takeaway

While an interesting off-label pharmaceutical approach, current evidence is inconclusive that naltrexone alone provides meaningful weight loss beyond three months for most individuals. As an adjunct under medical guidance, it may offer a slight advantage for appetite and craving control. However, data is lacking on safe long-term use, optimal dosing, ideal candidates, and isolated efficacy beyond initial studies.

Naltrexone for Weight Loss FAQs

Is naltrexone FDA-approved for weight loss treatment?
Answer: No, it is only currently FDA-approved for alcohol and opioid dependence treatment. Weight loss use is considered off-label.

Can anyone safely take naltrexone for dieting?
Answer: No, a thorough screening and risk assessment by a qualified prescriber is required beforehand due to serious potential side effects and drug interactions.

Should naltrexone be taken indefinitely for ongoing weight control?
Answer: No, chronic use safety data is insufficient at this time. Providers recommend short-term cycles only.

Does insurance cover naltrexone for weight loss?
Answer: Typically not, since this remains an off-label, experimental use of the drug. Out-of-pocket costs are required.

What happens when you stop taking naltrexone?
Answer: Effects wear off within 1-2 days with rebound overeating reportedly common. Lifestyle habits must be continued.


While naltrexone’s ability to reduce appetite shows initial promise, current evidence does not yet support its efficacy, safety, or practicality for most individuals as a long-term weight loss solution. Extensive additional research is still needed. Work closely with a qualified medical provider to determine if short-term supervised naltrexone use may be appropriate alongside diet, exercise, and behavioral changes.


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